SKELETAL PROGENITORS PRESERVE PROLIFERATION AND SELF-RENEWAL UPON INHIBITION OF MITOCHONDRIAL RESPIRATION BY REROUTING THE TCA CYCLE

Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

Summary: A functional electron transport chain (ETC) is crucial for supporting bioenergetics and biosynthesis.Accordingly, ETC inhibition Nail Forms decreases proliferation in cancer cells but does not seem to impair stem cell proliferation.However, it remains unclear how stem cells metabolically adapt.In this study, we show that pharmacological in

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Neonatal erythropoiesis and subsequent anemia in HIV-positive and HIV-negative Zimbabwean babies during the first year of life: a longitudinal study

Abstract Background Anemia is common in HIV infection long sleeve tee and independently associated with disease progression and mortality.The pathophysiology of HIV-related anemia is not well understood especially in infancy.Methods We conducted a longitudinal cohort study nested within the Zimbabwe Vitamin A for Mothers and Babies Project.We measu

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